Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging
Dementia and Neurocognitive Disorders
;
: 61-67, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-105260
ABSTRACT
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system. Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleterious role of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors for late-onset Alzheimer's disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset Alzheimer's disease. However, early-onset Alzheimer's disease has a weaker relationship with ε4 allele of apolipoprotein E.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Apolipoproteínas
/
Plasma
/
Encéfalo
/
Sistema Nervoso Central
/
Fatores de Risco
/
Alelos
/
Aterosclerose
/
Apolipoproteína E4
/
Doença de Alzheimer
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Idioma:
Inglês
Revista:
Dementia and Neurocognitive Disorders
Ano de publicação:
2016
Tipo de documento:
Artigo
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