Inhibitory effect of Erythronium japonicum on the human breast cancer cell metastasis
Nutrition Research and Practice
;
: 17-21, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-105459
ABSTRACT
BACKGROUND/OBJECTIVES:
In this study, the inhibitory effect of Erythronium japonicum extracts on the metastasis of MDA-MB-231 human breast cancer cell line was determined. MATERIALS/METHODS:
Cells were cultured with DMSO or with 50, 75, 100 or 250 microg/ml of Erythronium japonicum methanol or ethanol extract.RESULTS:
Both methanol and ethanol extracts significantly inhibited the growth and induced apoptosis of MDA-MB-231 cells in a dose-dependent manner. Erythronium japonicum extracts inhibited the adhesion of MDA-MB-231 cells. The invasion of breast cancer cells was suppressed by Erythronium japonicum extracts in a dose-dependent manner. The motility and MMP-2 and MMP-9 activities were also inhibited by both methanol and ethanol extracts.CONCLUSIONS:
Our results collectively indicate that Erythronium japonicum extracts inhibit the growth, adhesion, migration and invasion as well as induce the apoptosis of human breast cancer cells. Clinical application of Erythronium japonicum as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Mama
/
Linhagem Celular
/
Dimetil Sulfóxido
/
Apoptose
/
Etanol
/
Metanol
/
Metástase Neoplásica
Limite:
Humanos
Idioma:
Inglês
Revista:
Nutrition Research and Practice
Ano de publicação:
2015
Tipo de documento:
Artigo
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