Delayed Anaphylaxis to Red Meat Associated With Specific IgE Antibodies to Galactose
Allergy, Asthma & Immunology Research
;
: 92-94, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-105477
ABSTRACT
A novel delayed anaphylactic reaction to red meat, associated with tick bites and IgE antibodies against galactose-alpha-1, 3-galactose (alpha-gal), was reported in 2009 in the US, Australia and Europe. In this case, serum specific IgE to galactose-alpha-1, 3-galactose (>100 kU/L) and IgE to multiple non-primate mammalian proteins were positive. However, the pathogenesis of this disease remains unclear. We report the first case in Asia of delayed anaphylactic reaction to red meat, which was induced by bites from the hard tick, Hematophagous ixodidae. We confirmed the increased concentration of IgE reactive epitopes in non-primate mammalian organs, which may be rich in alpha-gal proteins in lymphatic and endothelial tissues. All confirmed ticks associated with this disorder in the literature and in our case belonged to the hard tick family. We hypothesize that hard tick saliva is enriched with blood-type substances, such as oligosaccharides, from the non-primate mammal victim's blood after days to weeks of blood sucking, which sensitizes humans through the injection route while blood sucking.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligossacarídeos
/
Ásia
/
Saliva
/
Austrália
/
Carrapatos
/
Imunoglobulina E
/
Ixodidae
/
Europa (Continente)
/
Picadas de Carrapatos
/
Hipersensibilidade Alimentar
Limite:
Humanos
País/Região como assunto:
Ásia
/
Europa
/
Oceania
Idioma:
Inglês
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2015
Tipo de documento:
Artigo
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