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No Association between Promoter Polymorphism of STK11 Gene and Lung Cancer Risk in the Korean Population / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 211-217, 2009.
Artigo em Inglês | WPRIM | ID: wpr-10557
ABSTRACT

PURPOSE:

Serine-threonine kinase11 (STK11) was originally identified in 1997 as the causative mutation that's responsible for Peutz-Jeghers Syndrome (PJS). Several recent studies have reported that the STK11 gene is an important human tumor suppressor gene in lung cancer. We evaluated the associations between the polymorphisms of the STK11 promoter region and the risk of lung cancer in 901 Koreans. MATERIALS AND

METHODS:

By direct sequencing, we first discovered three novel polymorphisms (-1,795 T>C, -981 C>T and -160 G>T) and four known polymorphisms (-1,580 C>T, -1,494 A>C, -881 A>G and -458 G>C) of the STK11 promoter region in 24 blood samples of 24 Korean lung cancer patients. Further genotype analyses were then performed on 443 lung cancer patients and 458 controls.

RESULTS:

We discovered three novel polymorphisms and we identified four known polymorphisms of the STK11 promoter region in a Korean population. Statistical analyses revealed that the genotypes and haplotypes in the STK11 gene were not significantly associated with the risk of lung cancer in a Korean population.

CONCLUSION:

This is the first study that's focused on the association of STK11 promoter polymorphisms and the risk of lung cancer in a Korean population. To evaluate the role of the STK11 gene for the risk of lung cancer, the genotypes of the STK11 promoter region (-1,795 T>C, -1,494 A>C and -160 G>T) were determined in 901 Koreans, yet the result revealed no significant difference between the lung cancer patients and the controls. These results suggest that the three promoter polymorphisms we studied are not important risk factors for the susceptibility to lung cancer in Koreans.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Haplótipos / Síndrome de Peutz-Jeghers / Fatores de Risco / Genes Supressores de Tumor / Regiões Promotoras Genéticas / Genótipo / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Haplótipos / Síndrome de Peutz-Jeghers / Fatores de Risco / Genes Supressores de Tumor / Regiões Promotoras Genéticas / Genótipo / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2009 Tipo de documento: Artigo