A Case of Wegener's Granulomatosis in the Orbital Area

ABSTRACT

Wegener`s granulomatosis(WG) is uncommon disease characterized by necrotizing granulomatous lesions in the both upper and lower respiratory tracts, generalized focal necrotizing vasculitis, and focal necrotizing glomerulonephritis. Other organs are also involved frequently. Ocular complications may occur secondary to contiguous granulomatous sinusitis or as a result of focal vasculitis and are encountered in 40-50% of cases of generalized form. We experienced a case of WG developed progressive paranasal sinusitis and rhinitis combined with orbital and ocular involvement. The diagnosis was confirmed by clinical findings and histopathologic features of tissue biopsy. The histopathology from periorbital area had typical findings of WG with necrotizing vasculitis and granuloma formation.