Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
The Korean Journal of Internal Medicine
;
: 176-182, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-105995
ABSTRACT
BACKGROUND/AIMS:
The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).METHODS:
Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups.RESULTS:
On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis.CONCLUSIONS:
Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Atrofia
/
Biópsia
/
Fibrose
/
Imuno-Histoquímica
/
Ativador de Plasminogênio Tipo Uroquinase
/
Biomarcadores
/
Inibidor 1 de Ativador de Plasminogênio
/
Podócitos
/
Receptores de Ativador de Plasminogênio Tipo Uroquinase
/
Glomerulonefrite por IGA
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo
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