Aberrant CpG Islands Hypermethylation Profiles in Malignant Gliomas
Brain Tumor Research and Treatment
;
: 29-35, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-106235
ABSTRACT
BACKGROUND:
The authors analyzed whether the promoter hypermethylation of cancer-related genes was involved in the tumorigenesis of malignant gliomas.METHODS:
A total of 29 patients received surgery and histologically confirmed to have malignant gliomas from January 2000 to December 2006. The promoter methylation status of several genes, which were reported to be frequently methylated in malignant gliomas, was investigated using methylation-specific polymerase chain reaction.RESULTS:
All cases of malignant gliomas represented the promoter hypermethylation in at least 2 or more genes tested. Of 29 tumors, 28 (96.55%) showed concurrent hypermethylation of 3 or more genes. Ras association domain family member 1, epithelial cadherin, O-6 methyl guanine DNA methyltransferase, thrombospondin 1, p14 and adenomatous polyposis coli were frequently methylated in high grade gliomas including glioblastomas, anaplastic astrocytomas, and anaplastic oligodendrogliomas.CONCLUSION:
Aberrant hypermethylation profile was closely related with malignant gliomas suggesting that epigenetic change may play a role in the development of malignant gliomas. Two or three target genes may provide useful clues to the development of the useful prognostic as well as diagnostic assays for malignant gliomas.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligodendroglioma
/
Astrocitoma
/
Neoplasias Encefálicas
/
DNA
/
Reação em Cadeia da Polimerase
/
Glioblastoma
/
Polipose Adenomatosa do Colo
/
Ilhas de CpG
/
Trombospondina 1
/
Epigenômica
Limite:
Humanos
Idioma:
Inglês
Revista:
Brain Tumor Research and Treatment
Ano de publicação:
2014
Tipo de documento:
Artigo
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