Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development
Brain Tumor Research and Treatment
;
: 1-6, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-106238
ABSTRACT
More than 98% of eukaryotic transcriptomes are composed of non-coding RNAs with no functional protein-coding capacity. Those transcripts also include tens of thousands of long non-coding RNAs (lncRNAs) which are emerging as key elements of cellular homeostasis, essentially tumorigenesis steps. However, we are only beginning to understand the nature and extent of the involvement of lncRNAs on tumorigeneis. Here, we highlight recent progresses that have identified a myriad of molecular functions on tumorigenesis for several lncRNAs including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1), H19, and homeobox transcript antisense intergenic RNA (HOTAIR), and several new lncRNAs for glioma development. Potential therapeutic approaches for the lncRNAs in various human diseases are also discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Próstata
/
RNA
/
Adenocarcinoma
/
Expressão Gênica
/
Genes Homeobox
/
Estimulação Elétrica Nervosa Transcutânea
/
RNA não Traduzido
/
RNA Longo não Codificante
/
Carcinogênese
/
Glioma
Limite:
Humanos
Idioma:
Inglês
Revista:
Brain Tumor Research and Treatment
Ano de publicação:
2014
Tipo de documento:
Artigo
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