Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 488-492, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-106334
ABSTRACT
BACKGROUND:
This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy.METHODS:
In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively.RESULTS:
Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group.CONCLUSIONS:
Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Período Pós-Operatório
/
Benzimidazóis
/
Anafilaxia Cutânea Passiva
/
Incidência
/
Estudos Prospectivos
/
Analgesia Controlada pelo Paciente
/
Ondansetron
/
Náusea e Vômito Pós-Operatórios
/
Antagonistas do Receptor 5-HT3 de Serotonina
/
Histerectomia
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2011
Tipo de documento:
Artigo
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