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Meta-Analysis of the Relationship between CXCR4 Expression and Metastasis in Prostate Cancer
The World Journal of Men's Health ; : 167-175, 2014.
Artigo em Inglês | WPRIM | ID: wpr-106555
ABSTRACT

PURPOSE:

Experimental studies have suggested that the stromal-derived factor-1 (SDF-1)/CXCR4 axis is associated with tumor aggressiveness and metastasis in several malignancies. We performed a meta-analysis to elucidate the relationship between CXCR4 expression and the clinicopathological features of prostate cancer. MATERIALS AND

METHODS:

Data were collected from studies comparing Gleason score, T stage, and the presence of metastasis with CXCR4 levels in human prostate cancer samples. The studies were pooled, and the odds ratio (OR) of CXCR4 expression for clinical and pathological variables was calculated.

RESULTS:

Five articles were eligible for the current meta-analysis. We found no relationship between CXCR4 expression and Gleason score ( or =7). The forest plot using the fixed-effects model indicated an OR of 1.585 (95% confidence interval [CI] 0.793~3.171; p=0.193). Further, CXCR4 expression was not associated with the T stage ( or =T3), and the relevant meta-analysis showed OR=1.803 (95% CI 0.756~4.297, p=0.183). However, increased CXCR4 expression was strongly associated with metastatic disease with a fixed-effects pooled OR of 7.459 (95% CI 2.665~20.878, p<0.001).

CONCLUSIONS:

Our meta-analysis showed that the higher CXCR4 protein expression in prostate cancer specimens is significantly associated with the presence of metastatic disease. This supports previous experimental data supporting the role played by the SDF-1/CXCR4 axis in metastasis.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Próstata / Vértebra Cervical Áxis / Razão de Chances / Receptores CXCR4 / Gradação de Tumores / Metástase Neoplásica Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Inglês Revista: The World Journal of Men's Health Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Próstata / Vértebra Cervical Áxis / Razão de Chances / Receptores CXCR4 / Gradação de Tumores / Metástase Neoplásica Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Inglês Revista: The World Journal of Men's Health Ano de publicação: 2014 Tipo de documento: Artigo