Near-tetraploidy Acute Myeloid Leukemia with RUNX1-RUNX1T1 Rearrangement Due to Cryptic t(8;21) / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 510-514, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-106766
ABSTRACT
Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to be specifically associated with t(8;21). In this case report, FISH analysis detected RUNX1-RUNX1T1 gene rearrangement in the absence of cytogenetic abnormality of t(8;21), which suggests the presence of unvailed t(8;21). This is the first case report of tetraploidy or near-tetraploidy AML with cryptic RUNX1/RUNX1T1 in Korea. Although the prognosis of tetraploidy or near- tetraploidy with t(8;21) is known to be poor, this patient shows a relatively good clinical course compared to other reported cases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Poliploidia
/
Fatores de Transcrição
/
Translocação Genética
/
Cromossomos Humanos Par 8
/
Cromossomos Humanos Par 21
/
Rearranjo Gênico
/
Leucemia Mieloide Aguda
/
Proteínas Proto-Oncogênicas
/
Hibridização in Situ Fluorescente
/
Subunidade alfa 2 de Fator de Ligação ao Core
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2009
Tipo de documento:
Artigo
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