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Chemotherapy induced liver abnormalities: an imaging perspective
Clinical and Molecular Hepatology ; : 317-326, 2014.
Artigo em Inglês | WPRIM | ID: wpr-106791
ABSTRACT
Treating patients undergoing chemotherapy who display findings of liver toxicity, requires a solid understanding of these medications. It is important for any clinician to have an index of suspicion for liver toxicity and be able to recognize it, even on imaging. Cancer chemotherapy has evolved, and newer medications that target cell biology have a different pattern of liver toxicity and may differ from the more traditional cytotoxic agents. There are several hepatic conditions that can result and keen clinical as well as radiographic recognition are paramount. Conditions such as sinusoidal obstructive syndrome, steatosis, and pseudocirrhosis are more commonly associated with chemotherapy. These conditions can display clinical signs of acute hepatitis, liver cirrhosis, and even liver failure. It is important to anticipate and recognize these adverse reactions and thus appropriate clinical action can be taken. Often times, patients with these liver manifestations can be managed with supportive therapies, and liver toxicity may resolve after discontinuation of chemotherapy.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tomografia Computadorizada por Raios X / Antineoplásicos Alquilantes / Inibidores Enzimáticos / Fígado Gorduroso / Doença Hepática Induzida por Substâncias e Drogas / Imunoterapia / Cirrose Hepática / Hepatopatias / Antibióticos Antineoplásicos / Neoplasias Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clinical and Molecular Hepatology Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tomografia Computadorizada por Raios X / Antineoplásicos Alquilantes / Inibidores Enzimáticos / Fígado Gorduroso / Doença Hepática Induzida por Substâncias e Drogas / Imunoterapia / Cirrose Hepática / Hepatopatias / Antibióticos Antineoplásicos / Neoplasias Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clinical and Molecular Hepatology Ano de publicação: 2014 Tipo de documento: Artigo