Sole Trisomy 22 Not Associated with inv(16) in Myelodysplastic Syndrome / 이화의대지
The Ewha Medical Journal
;
: 62-64, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-107396
ABSTRACT
Trisomy 22 is closely associated with inv(16) or t(16;16) and could be a marker of cryptic rearrangement of CBFB/MYH11 in acute myeloid leukemia (AML). Trisomy 22 not associated with CBFB/MYH11 rearrangement is a rare event. Here, we report a case diagnosed as refractory anemia with excess blasts-2 (RAEB-2) with sole trisomy 22 in the absence of CBFB/MYH11 rearrangement. The cytogenetic study of bone marrow cells disclosed trisomy 22 in 10% of metaphase cells analyzed. The other chromosomal abnormalities were not found. Fluorescence in situ hybridization (FISH) using CBFB/MYH11 probe to detect cryptic inv(16)(p13q22) showed negative result. We also excluded rearrangements of chromosome 5, 7, 8, 20, and ETV6 by FISH. Sole trisomy 22 not associated with inv(16) is a true entity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Trissomia
/
Síndromes Mielodisplásicas
/
Cromossomos Humanos Par 5
/
Cromossomos Humanos Par 22
/
Anemia Refratária
/
Células da Medula Óssea
/
Leucemia Mieloide Aguda
/
Aberrações Cromossômicas
/
Hibridização In Situ
/
Citogenética
Idioma:
Inglês
Revista:
The Ewha Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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