Cytotoxicity of gamma-ray in rat immature hippocampal neurons
Journal of Veterinary Science
;
: 203-207, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-108033
ABSTRACT
This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy gamma-rays. Cytotoxicity was analyzed using a lactate dehydrogenase release assay at 24 h after gamma-irradiation. Radiation-induced cytotoxicity in immature hippocampal neurons increased in a dose-dependent manner. Pre-treatments of pro-apoptotic caspase inhibitors and anti-oxidative substances significantly blocked gamma-irradiation-induced cytotoxicity in immature hippocampal neurons. The results suggest that the caspase-dependent cytotoxicity of gamma-rays in immature hippocampal cultured neurons may be caused by oxidative stress.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Catequina
/
Sobrevivência Celular
/
Células Cultivadas
/
Poli(ADP-Ribose) Polimerases
/
Ratos Sprague-Dawley
/
Amifostina
/
Relação Dose-Resposta à Radiação
/
Caspase 3
/
Raios gama
/
Hipocampo
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS