Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
Biomolecules & Therapeutics
;
: 343-348, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-108279
ABSTRACT
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
United States Food and Drug Administration
/
Simulação por Computador
/
Programas de Rastreamento
/
Monofenol Mono-Oxigenase
/
Melanossomas
/
Epiderme
/
Hesperidina
/
Coreia (Geográfico)
/
Melaninas
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2013
Tipo de documento:
Artigo
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