Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy
Biomolecules & Therapeutics
; : 323-331, 2013.
Article
em En
| WPRIM
| ID: wpr-108282
Biblioteca responsável:
WPRO
ABSTRACT
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Neoplasias da Mama
/
Fator de Crescimento Transformador beta
/
Metástase Neoplásica
Idioma:
En
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2013
Tipo de documento:
Article