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Effects of Non-steroidal Anti-inflammatory Drug on Anterior Uveitis
Journal of the Korean Ophthalmological Society ; : 1287-1294, 1995.
Artigo em Coreano | WPRIM | ID: wpr-108928
ABSTRACT
To evaluate effects of the topical administration of non-steroidal antiinflammatory drug on anterior uveitis, suprofen eye drop was instilled into the left eye of 10 pigmented rabbits and then experimental anterior uveitis was induced by injecting 750 mocro gram/kg endotoxin of Shigella flexneri serotype 1A into their peritoneal cavities. The pupillary diameters were measured, and cell and flare gradings were recorded in 20 eyes of 10 rabbits for one week at an interval of 12 hours for the first day and then daily. Differences between the treatment and control groups were investigated. All the above parameters showed greatest changes at 12 or 24 hours after the injection of endotoxin and became normal by one week. The treatment and the control groups demonstrated statistically significant difference at 12 hours, day 1, and day 2 as for pupillary diameter and at day 1 and day 2 as for cell and at 12 hours and day 1 as for flare. Thus, it is concluded that prostaglandin plays a role in miosis and the appearance of inflammatory cells and flare in anterior uveitis and the topical administration of non-steroidal anti-inflammatory drug can alleviate signs of anterior uveitis. The specific relationship between leucotriene B4 and polymorphonuclear leucocytes influx was not demonstrated.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Shigella flexneri / Miose / Suprofeno / Uveíte Anterior / Administração Tópica Limite: Animais Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Ano de publicação: 1995 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Shigella flexneri / Miose / Suprofeno / Uveíte Anterior / Administração Tópica Limite: Animais Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Ano de publicação: 1995 Tipo de documento: Artigo