Perinatal Prognosis According to Thyroid Function in Pregnant Women with Thyroid Disease / 대한주산의학회잡지

ABSTRACT

OBGECTIVE The purpose of this study is to evaluate perinatal outcomes according to thyroid function in pregnant women with thyroid disease. METHODS: The retrospective study was made by review of medical records of 42 pregnant women with thyroid disease (hyperthyroidism22 cases, hypothyroidism20 cases) who had delivered between Jan 2001 to Oct 2005. Clinical features and thyroid hormone levels were compared between the women who were managed during pregnancy (treating group) and not managed during pregnancy who had been cured (cured group). RESULTS:In pregnant women with hyperthyroidism, treating group showed higher T3 and T4, lower TSH than cured group, but there was no difference in neonatal thyroid hormone levels between two groups. In the women with thyroid storm, all thyroid hormone levels were significantly different from those in women without thyroid storm, but in newborn of women with thyroid storm, only TSH level was significantly lower. In the pregnant women with hypothyroidism who were treated appropriate levothyroxine, almost women maintained euthyroid hormone levels during pregnancy. CONCLUSION:Early diagnosis and treatment for thyroid disease before pregnancy may prevent perinatal complications. Team approach of obstetrician, endocrinologist and neonatalogist may help for maternal and fetal well-being.