Associated Factors with Parenteral Nutrition Associated Cholestasis in Neonates / 소아외과
Journal of the Korean Association of Pediatric Surgeons
;
: 1-6, 2015.
Artigo
em Coreano
| WPRIM
| ID: wpr-109293
ABSTRACT
PURPOSE:
Long time total parenteral nutrition (TPN) can induce irreversible liver damage. In this study, we investigated the associated factors of parenteral nutrition associated cholestasis (PNAC) in neonates.METHODS:
We retrospectively reviewed 227 neonates (malefemale=110117) those who had received TPN over 2 weeks from March 2010 to February 2014. PNAC was defined as direct bilirubin was higher than 2.0 mg/dL without any cause except TPN.RESULTS:
Overall incidence was 28.6%. PNAC was frequently developed in younger gestational age with lower birth weight. Episodes of sepsis, underlying bronchopulmonary dysplasia, history of necrotizing enterocolitis, and experience of gastrointestinal surgery increase the incidence of PNAC. PNAC was directly associated the duration of TPN and long period to full enteral feeding, reaching 60 and 150 mL/kg/day. Overall mortality rate was 9.7%. It was higher in PNAC group despite PNAC was not the primary cause of death. All survivors were recovered from cholestasis with encourage of enteral nutrition.CONCLUSION:
PNAC in neonate was associated with younger gestational ages and lower birth weights, duration of TPN, or who experienced sepsis, necrotizing enterocolitis, gastrointestinal surgery or bronchopulmonary dysplasia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bilirrubina
/
Peso ao Nascer
/
Displasia Broncopulmonar
/
Colestase
/
Incidência
/
Estudos Retrospectivos
/
Mortalidade
/
Causas de Morte
/
Idade Gestacional
/
Nutrição Enteral
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
/
Recém-Nascido
Idioma:
Coreano
Revista:
Journal of the Korean Association of Pediatric Surgeons
Ano de publicação:
2015
Tipo de documento:
Artigo
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