NF-kappa B activation following optic nerve transection
Korean Journal of Ophthalmology
; : 19-24, 1998.
Article
em En
| WPRIM
| ID: wpr-10934
Biblioteca responsável:
WPRO
ABSTRACT
In order to elucidate in vivo neuronal cell death in the retina, and involvement of NF-kappa B in this process, we studied the degeneration of retinal ganglion cells (RGCs) and the activation of NF-kappa B after transection of the optic nerve of adult rat at 5 mm from the eyeball. The morphology of dying ganglion cells in the retinal ganglion cell layer was observed by light and electron microscopy, the activation of NF-kappa B was investigated immunohistochemically. Seven and 14 days post-axotomy, dying cells contained pyknotic nuclei. The death of retinal ganglion cells involved apoptosis, activation of NF-kappa B (p50 and p65) was prominent in a time dependent manner. We observed axotomy-induced NF-kappa B activation, which may mediate apoptosis of retinal ganglion cells.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Nervo Óptico
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Células Ganglionares da Retina
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Imuno-Histoquímica
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Microscopia Eletrônica
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NF-kappa B
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Ratos Sprague-Dawley
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Apoptose
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Axotomia
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Animais
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
1998
Tipo de documento:
Article