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Efficacy and Toxicity of Mammalian Target Rapamycin Inhibitors in Patients with Metastatic Renal Cell Carcinoma with Renal Insufficiency: The Korean Cancer Study Group GU 14-08 / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1286-1292, 2016.
Artigo em Inglês | WPRIM | ID: wpr-109748
ABSTRACT

PURPOSE:

We evaluated the efficacy and toxicity of mammalian target rapamycin inhibitors in Korean patients with metastatic renal cell carcinoma (mRCC) with chronic renal insufficiency not requiring dialysis. MATERIALS AND

METHODS:

Korean patients with mRCC and chronic renal insufficiency not requiring dialysis treated with everolimus or temsirolimus between January 2008 and December 2014 were included. Patient characteristics, clinical outcomes, and toxicities were evaluated. Overall survival (OS) and progression-free survival (PFS) durations were evaluated according to the degree of renal impairment.

RESULTS:

Eighteen patients were considered eligible for the study (median age, 59 years). The median glomerular filtration rate was 51.5 mL/min/1.73 m². The best response was partial response in six patients and stable disease in 11 patients. The median PFS and OS durations were 8 months (95% confidence interval [CI], 0 to 20.4) and 32 months (95% CI, 27.5 to 36.5), respectively. The most common non-hematologic and grade 3/4 adverse events included stomatitis, fatigue, flu-like symptoms, and anorexia as well as elevated creatinine level.

CONCLUSION:

Mammalian target rapamycin inhibitors were efficacious and did not increase toxicity in Korean patients with mRCC and chronic renal insufficiency not requiring dialysis.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estomatite / Carcinoma de Células Renais / Anorexia / Intervalo Livre de Doença / Sirolimo / Creatinina / Diálise / Insuficiência Renal / Insuficiência Renal Crônica / Fadiga Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estomatite / Carcinoma de Células Renais / Anorexia / Intervalo Livre de Doença / Sirolimo / Creatinina / Diálise / Insuficiência Renal / Insuficiência Renal Crônica / Fadiga Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2016 Tipo de documento: Artigo