A Case of Neurofollicular Hamartoma / 대한피부과학회지

ABSTRACT

Neurofollicular hamartoma is an unusual, previously described neoplasm characterized by a stroma composed of proliferation of spindle cells and hyperplastic pilosebaceous units. The stroma has light microscopic and immunohistochemical features consistent with neuroid differentiation showing positive S-100 antigen. Lesions are almost invariably located on the face with strong predilection for the nose or nasolabial fold. A 35-year-old man presented with a solitary, skin-colored, dome-shaped papule that had been present on his right temple area for a few years. Clinical differential diagnosis included basal cell carcinoma, angiofibroma and intradermal nevus. Clinically, the lesion presents as a small, skin-colored, dome-shaped firm papule, 3 to 7 mm in diameter. Although clinical aspects of the lesion are not diagnostic, the histological features are very typical. Herein, we report a rare case of neurofollicular hamartoma on the right temple area.