New Trends of Preeclampsia / 대한산부인과학회지

ABSTRACT

Preeclampsia is a leading cause of death and disability in mothers and infants. It's cause remains unknown. The only effective treatment is delivery. Preeclampsia is currently believed to be a 2-stage disease. The first stage is characterized by shallow cytotrophoblast invasion of maternal spiral arteriole, resulting in placental insufficiency. There are no maternal signs and symptoms during this stage. The hypoxic placenta release soluble factors into maternal circulation, which induce systemic endothelial dysfunction. This cause the second stage of the disease the maternal syndrome. During this stage, the clinical signs of preeclampsia, are manifested. We review the evidence that an imbalance of circulating angiogenic factors, the prevention and treatment of preeclampsia including antioxidants for the prevention of preeclampsia, the expectant management and antihypertensive medications to treat mild and severe hypertension in women preeclampsia.