Occupational asthma induced by cephalosporin precursor / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 90-94, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-110740
ABSTRACT
A 41-year-old male pharmaceutical worker developed dyspnea and wheezing 10 years after beginning the work. He had handled powder of cephalosporin precursor, 7-aminocephalosporanic acid (7-ACA). He had suffered from dyspnea, chest tightness and wheezing in the workplace for the last three years. Recently, these symptoms were aggravated. His pulmonary function test showed severe obstructive pattern and PC(20) was 0.06 mg/ml on MBPT(methacholine bronchial provocation test). Skin prick test and intradermal test showed positive reactions to ceftriaxone, cefazolin, etc. During the skin test, he suffered from an asthmatic attack and anaphylactic shock. Bronchial provocation test with cefotiam elicited a dual asthmatic reaction. We presumed that IgE-mediated mechanism may be mainly involved in the pathogenesis of cephalosporin induced occupational asthma, in addition to other immunologic or non-immunologic mechanisms. Further studies will be necessary to investigate the pathogenesis of this disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testes de Função Respiratória
/
Pele
/
Tórax
/
Ceftriaxona
/
Testes de Provocação Brônquica
/
Testes Intradérmicos
/
Testes Cutâneos
/
Cefotiam
/
Cefazolina
/
Sons Respiratórios
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Ano de publicação:
2003
Tipo de documento:
Artigo
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