Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats
Journal of Veterinary Science
;
: 97-102, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-110760
ABSTRACT
We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Traumatismos da Medula Espinal
/
Ensaio de Imunoadsorção Enzimática
/
Regulação da Expressão Gênica
/
Fator Neurotrófico Derivado do Encéfalo
/
Fator de Crescimento Neural
/
Perfilação da Expressão Gênica
/
Transplante de Células-Tronco de Sangue do Cordão Umbilical
/
Locomoção
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2016
Tipo de documento:
Artigo
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