The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
Experimental & Molecular Medicine
;
: e201-2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-111602
ABSTRACT
Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência à Insulina
/
Sirolimo
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Aminoácidos
/
Insulina
/
Lisossomos
/
Metabolismo
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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