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Interferon Treatment on HBeAg Positive Chronic Hepatitis B with HBV Precore Mutant in Liver Tissue / 대한내과학회지
Korean Journal of Medicine ; : 43-51, 1998.
Artigo em Coreano | WPRIM | ID: wpr-111627
ABSTRACT

BACKGROUND:

This study investigates the prevalance of HBV precore mutant in chronic B hepatitis patients and whether HBV precore mutants affect hepatic inflammation and response to interferon alfa.

METHODS:

HBV DNA in liver tissue from 48 chronic hepatitis patients was amplified by polymerase chain reaction. The HBV precore mutants were detected by direct sequencing of amplified PCR products. Thirty-three HBeAg-positive patients (Group 1 wild- type, Group 2 mixed) were received 3-6 MU INF three times a week for 4-6 months. We did follow-ups for at least six months(mean Group 1-11.3, Group 2- 13.7 months). A complete responder was defined as persistent(>6 months) normalization of transaminase and loss of HBeAg and/or seroconversion.

RESULTS:

The HBV precore mutants were found in 15 cases(31.2%) among 48 patients 7 cases(21.2%) in 33 HBeAg-positive patients and 8 cases(53.3%) in 15 HBeAg-negative patients. The HBV precore mutants were more frequently found in HBeAg-negative patients(p= 0.043). Differences in severity of hepatic pathology were not observed in the wild-type versus mutant-type chronic hepatitis B patients(p =1.00). Initial response rate was not significantly different between two Groups(p= 0.228), but complete response rate had a lower tendency in Group 2 (p=0.073).

CONCLUSION:

There is a tendency for HBV precore mutants to be less responsive to INF therapy than wild type. Therefore the patients with chronic hepatitis B should be treated as early as possible in natural history of their liver disease before the emergence of HBV precore mutants.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / DNA / Reação em Cadeia da Polimerase / Seguimentos / Interferons / Interferon-alfa / História Natural / Hepatite B Crônica / Hepatite / Antígenos E da Hepatite B Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / DNA / Reação em Cadeia da Polimerase / Seguimentos / Interferons / Interferon-alfa / História Natural / Hepatite B Crônica / Hepatite / Antígenos E da Hepatite B Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 1998 Tipo de documento: Artigo