Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APC(Min/+) Intestinal Polyposis Model
Journal of Cancer Prevention
;
: 193-201, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-112061
ABSTRACT
BACKGROUND:
Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.METHODS:
APC(Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with beta-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of beta-catenin were determined.RESULTS:
The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic beta-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group.CONCLUSIONS:
These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by beta-catenin associated signals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glycine max
/
Estresse Oxidativo
/
Citosol
/
Polipose Intestinal
/
Dieta
/
Ciclo-Oxigenase 2
/
Beta Catenina
/
Fosfolipases A2
/
Carcinogênese
/
Inflamação
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Cancer Prevention
Ano de publicação:
2015
Tipo de documento:
Artigo
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