Anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans / 한국실험동물학회지
Laboratory Animal Research
; : 131-135, 2014.
Article
em En
| WPRIM
| ID: wpr-112260
Biblioteca responsável:
WPRO
ABSTRACT
Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1x10(9) CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pepsinogênios
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Bactérias
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Ureia
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Testes Respiratórios
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Oenothera biennis
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Helicobacter pylori
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Helicobacter
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Pepsinogênio A
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Mucosa Gástrica
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Laboratory Animal Research
Ano de publicação:
2014
Tipo de documento:
Article