Significant fibrosis after radiation therapy in a patient with Marfan syndrome
Radiation Oncology Journal
;
: 208-212, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-112697
ABSTRACT
Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor beta 1 (TGF-beta1) can be monitored as a predictor of subsequent fibrosis in this population of high risk patients. We therefore monitored the patient's TGF-beta1 level during and after treatment. Despite maintaining stable levels of plasma TGF-beta1, our patient still developed extensive fibrosis resulting in impaired range of motion. Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Doenças Vasculares
/
Fibrose
/
Plexo Braquial
/
Biomarcadores
/
Amplitude de Movimento Articular
/
Fator de Crescimento Transformador beta
/
Colágeno
/
Diagnóstico
/
Fator de Crescimento Transformador beta1
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Radiation Oncology Journal
Ano de publicação:
2014
Tipo de documento:
Artigo
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