Antimicrobial effect of cefixime on 6 species of periodotopathogens / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
; : 401-411, 2005.
Article
em Ko
| WPRIM
| ID: wpr-112936
Biblioteca responsável:
WPRO
ABSTRACT
The aim of this study was to determine the minimal inhibitory concentration(MIC) of cefi- xime, which is a 3rd generation of cefalosporin, against 6 species of putative periodon- topathogens; Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Prevotella inter- media, Prevotella nigrescens, Tannerella forsythia and Porphyromonas gingivalis. The efficacy of cefixime was examined by comparing it with that of several antibiotics(amoxicillin, Aug- mentin(R) ciprofloxacin, metronidazole, and tetracycline), which were used as the control. The MIC was measured using a microdilution method. The MIC of cefixime against the putative periodotopathogens, as a single use regimen, was relatively lower than that of the other antibiotics. The MIC of cefixime/metronidazole against P. intermedia ChDC KB14, P. nigres- cens ChDC KB50, F. nucleatum ChDC PV-F37, F. nucleatum ChDC F130, and F. nucleatum ChDC F175, as a simultaneous regimen, was lower than that of the other antibiotics. The concentration of cefixime in the crevicular fluid of volunteers who received 250mg every 12 hours for 3 days was 9microgram/ml after 9 hours. In conclusion, cefixime showed good anti- microbial activity in a single treatment or as a combined therapy with amoxicillin, Aug- mentin(R) or metronidazole against 6 periodontopathogens.
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Índice:
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Assunto principal:
Voluntários
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Ciprofloxacina
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Fusobacterium nucleatum
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Aggregatibacter actinomycetemcomitans
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Porphyromonas gingivalis
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Prevotella
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Cefixima
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Forsythia
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Prevotella nigrescens
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Amoxicilina
Idioma:
Ko
Revista:
The Journal of the Korean Academy of Periodontology
Ano de publicação:
2005
Tipo de documento:
Article