Effect of the combined use of bone morphogenetic protein and platelet-derived growth factor on bone formation in nude mouse / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 263-269, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-112948
ABSTRACT
Bone morphogenetic protein(BMP) and platelet-derived growth factor(PDGF) have been demonstrated tostimulate bone formation when applied locally in vivo. To explore whether or not the combined use of BMP and PDGF could have promotive effect and synergic interac- tion on bone formation in vivo, bone marrow mesenchymal stem cells were treated with BMP-2, PDGF-BB, or BMP-2 plus PDGF-BB, and then these cells were injected into the subcutaneous space on the dorsum of nude mice. The bone formation was evaluated after 12 weeks. Histomorphometric analysis demonstrated that the subcutaneous nodules formed in nude mice contained 25.3% newly formed bone in the BMP-2 treated cells, 14.4% newly formed bone in the PDGF-BB treated cells, and 8.9% newly formed bone in the BMP-2 plus PDGF-BB treated cells. The results showed that the combination of BMP-2 and PDGF-BB had neither a promotive effect nor synergic interact on bone formation in vivo.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Medula Óssea
/
Fator de Crescimento Derivado de Plaquetas
/
Proteínas Morfogenéticas Ósseas
/
Células-Tronco Mesenquimais
/
Camundongos Nus
Limite:
Animais
Idioma:
Coreano
Revista:
The Journal of the Korean Academy of Periodontology
Ano de publicação:
2005
Tipo de documento:
Artigo
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