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Non-typhoidal Salmonella Gastroenteritis in Childhood: Clinical Features and Antibiotics Resistance / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition ; : 150-157, 2002.
Artigo em Coreano | WPRIM | ID: wpr-112963
ABSTRACT

PURPOSE:

As the incidence of non-typhoidal salmonella strains resistant to antibiotics has been increased, we attempted to investigate clinical aspects of non-typhoidal salmonella gastroenteritis and antibiotics resistance.

METHODS:

From January 2000 to June 2002, 99 children with positive stool culture of non-typhoidal salmonella were studied about clinical features, the incidence of antibiotics and multi-drug resistance and the difference of incidence of antibiotics resistance according to immune status.

RESULTS:

There were 66 males and 33 females. The majority of them were under 5 years of age (71%). 25 children were immunocompromised due to chemotherapy, steroid or immunosuppressive treatment. Serogroup D was the most common isolates (65%) followed by B (16%), C (8%) and E (8%). Resistance rate of 30% to ampicillin, 12% to chloramphenicol, 20% to trimethoprim- sulfamethoxazole (TMP-SMX), 11% to cefotaxime and 8% to cefixime were obtained. All isolates were susceptible to ciprofloxacine. Resistance rate to cefotaxime and cefixime in immunocompromised patients was 24% and 14.3% respectively, which were significantly higher compared to that in immunocompetent patients (6.8%, 5.6%, p<0.05). 11 isolates were resistant to three or more antibiotics. The incidence of multi-drug resistant isolates was significantly higher in immunocompromised patients (24%) than that of immunocompetent patients (6.8%).

CONCLUSION:

Because of the high prevalence of non-typhoidal salmonella strains resistant to ampicillin, chloramphenicol and TMP-SMX, third-generation cephalosporin might be the treatment of choice in non-typhoidal salmonella gastroenteritis. In particular, antibiotics should be carefully selected in immunocompromised patients because non-typhoidal salmonellas from them showed the higher incidence of antibiotic resistance and multi-drug resistance.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Salmonella / Sulfametoxazol / Resistência Microbiana a Medicamentos / Ciprofloxacina / Cefotaxima / Combinação Trimetoprima e Sulfametoxazol / Cloranfenicol / Incidência / Prevalência / Hospedeiro Imunocomprometido Tipo de estudo: Estudo de incidência / Estudo de prevalência / Estudo prognóstico Limite: Criança / Feminino / Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Pediatric Gastroenterology and Nutrition Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Salmonella / Sulfametoxazol / Resistência Microbiana a Medicamentos / Ciprofloxacina / Cefotaxima / Combinação Trimetoprima e Sulfametoxazol / Cloranfenicol / Incidência / Prevalência / Hospedeiro Imunocomprometido Tipo de estudo: Estudo de incidência / Estudo de prevalência / Estudo prognóstico Limite: Criança / Feminino / Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Pediatric Gastroenterology and Nutrition Ano de publicação: 2002 Tipo de documento: Artigo