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Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study
Journal of Periodontal & Implant Science ; : 136-143, 2012.
Artigo em Inglês | WPRIM | ID: wpr-11333
ABSTRACT

PURPOSE:

The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model.

METHODS:

Mini-implants (phi1.8x12 mm) were installed in MBCP blocks (bMBCPs, 4x5x15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated.

RESULTS:

Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23+/-4.13% (mean+/-standard deviation), while bone density was 33.47+/-5.73%. In contrast, no bone formation was observed in the bMBCP only group.

CONCLUSIONS:

This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Titânio / Proteínas Recombinantes / Densidade Óssea / Implantes Dentários / Cálcio / Osseointegração / Fator de Crescimento Transformador beta / Ratos Sprague-Dawley / Proteína Morfogenética Óssea 2 Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Journal of Periodontal & Implant Science Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Titânio / Proteínas Recombinantes / Densidade Óssea / Implantes Dentários / Cálcio / Osseointegração / Fator de Crescimento Transformador beta / Ratos Sprague-Dawley / Proteína Morfogenética Óssea 2 Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Journal of Periodontal & Implant Science Ano de publicação: 2012 Tipo de documento: Artigo