A Case of Macropharge Activation Syndrome Successfully Treated with Combination Therapy Including Etanercept
Journal of Rheumatic Diseases
;
: 225-229, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-11340
ABSTRACT
Macrophage activation syndrome (MAS) is a severe, potentially life-threatening complication of childhood systemic inflammatory disorder, primarily systemic onset juvenile rheumatoid arthritis (SoJRA). It is characterized by pancytopenia, liver insufficiency, coagulopathy, and neurologic symptoms. The clinical manifestations are caused by the activation and uncontrolled proliferation of T lymphocytes and macrophages, leading to cytokine overproduction including tumor necrosis factor-alpha (TNF-alpha). Methylprednisolone pulse therapy and cyclosporine A have made a considerable progress in the treatment of MAS. However, the mortality rate remains high suggesting the need of another therapeutic agent. Several cases of MAS successfully treated with TNF-alpha inhibitor (etanercept) have been reported. We report the first Korean case of MAS successfully treated with combination therapy of corticosteroid, cyclosporine A and etanercept.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancitopenia
/
Artrite Juvenil
/
Imunoglobulina G
/
Metilprednisolona
/
Linfócitos T
/
Fator de Necrose Tumoral alfa
/
Ciclosporina
/
Receptores do Fator de Necrose Tumoral
/
Insuficiência Hepática
/
Síndrome de Ativação Macrofágica
Idioma:
Coreano
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS