Your browser doesn't support javascript.
loading
Phase II Study to Topotecan and Cisplatin in Advanced Hepatocellular Carcinoma
The Korean Journal of Internal Medicine ; : 104-108, 2003.
Artigo em Inglês | WPRIM | ID: wpr-113823
ABSTRACT

BACKGROUND:

Hepatocellular carcinoma remains a highly chemoresistant neoplasm and is a common malignancy with poor prognosis in Korea. We performed a phase II study to evaluate the efficacy and toxicities of topotecan and cisplatin combination chemotherapy for advanced hepatocellular carcinoma.

METHODS:

Between November 1999 and May 2001, ten patients with histologically proven hepatocellular carcinoma were enrolled in this study. The median age was 54 (range 53~74) years and all were male. Six patients demonstrated stage IV, 1 stage IIIC, 2 stage IIIB and 1 stage IIIA. Six patients showed a ECOG performance status of 1. The treatment regimen consisted of topotecan 1.25 mg/m2 and cisplatin 20 mg/m2 for 5 days. The treatment was repeated every 4 weeks. Toxicities were evaluated according to WHO toxicity criteria.

RESULTS:

All ten patients were evaluable for response and toxicity. There was only one patient who achieved partial response. The overall response rate was 10% (95% C.I.) and the response duration was 46 weeks. The median survival of all patients was 21 (range 17~54+) weeks. During a total of 24 cycles, neutropenia of WHO grade 3 and 4 occurred in 33%, thrombocytopenia in 33% and anemia in 21%. In non-hematologic toxicity, diarrhea and hepatoxicity of grade 3 occurred in 1 and 2 patients, respectively. But there was no treatment-related death.

CONCLUSION:

When used in this dose and schedule, topotecan and cisplatin combination chemotherapy does not seem to be effective for patients with advanced hepatocellular carcinoma.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Cisplatino / Resultado do Tratamento / Carcinoma Hepatocelular / Topotecan / Neoplasias Hepáticas Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: The Korean Journal of Internal Medicine Ano de publicação: 2003 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Cisplatino / Resultado do Tratamento / Carcinoma Hepatocelular / Topotecan / Neoplasias Hepáticas Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: The Korean Journal of Internal Medicine Ano de publicação: 2003 Tipo de documento: Artigo