Clinical Factors Associated with Acquisition of Resistance to Levofloxacin in Stenotrophomonas maltophilia
Yonsei Medical Journal
;
: 987-993, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-113977
ABSTRACT
PURPOSE:
Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. MATERIALS ANDMETHODS:
Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in > or =3 serial SMP isolates.RESULTS:
We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08-76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16-20.24, p=0.030) were independently associated with LFr acquisition in SMP.CONCLUSION:
Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testes de Sensibilidade Microbiana
/
Estudos Retrospectivos
/
Infecções por Bactérias Gram-Negativas
/
Stenotrophomonas maltophilia
/
Fluoroquinolonas
/
Levofloxacino
/
Antibacterianos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2014
Tipo de documento:
Artigo
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