A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 294-297, 2010.
Article
em Ko
| WPRIM
| ID: wpr-114968
Biblioteca responsável:
WPRO
ABSTRACT
Although Taxol(R) is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, "C activation-related pseudo-allergy". Most severe hypersenstivity reactions occur within the first few minutes of Taxol(R) administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PM(R) infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PM(R) infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Púrpura
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Proteínas do Sistema Complemento
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Metilprednisolona
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Epinefrina
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Paclitaxel
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Exantema
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Hipersensibilidade
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Hipersensibilidade Tardia
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Hipotensão
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Anafilaxia
Limite:
Aged
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Humans
Idioma:
Ko
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2010
Tipo de documento:
Article