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Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis
Annals of Dermatology ; : 10-14, 2015.
Artigo em Inglês | WPRIM | ID: wpr-11507
ABSTRACT

BACKGROUND:

Vitamin D insufficiency could be associated with the prevalence of atopic dermatitis (AD).

OBJECTIVE:

To examine vitamin D status and the relations between serum 25-hydroxyvitamin D levels, SCORAD score, serum LL-37 level, and body mass index (BMI) in Korean AD patients, and to explore whether these associations differ between adults and children.

METHODS:

Serum 25-hydroxyvitamin D levels, serum LL-37, and clinical features were analyzed in a total of 72 Korean patients with AD (39 adults and 33 children) and 140 healthy control subjects (70 adults and 70 children).

RESULTS:

Serum 25-hydroxyvitamin D levels were significantly reduced in children with AD (15.06+/-4.64 ng/ml) compared with normal children in the control group (16.25+/-6.60 ng/ml) (p=0.036). Significant inverse correlations were found between BMI and 25-hydroxyvitamin D level (r=-0.315, p=0.007) and between the SCORAD score and serum LL-37 level (r=-0.3, p=0.011) in the total AD patients.

CONCLUSION:

The results showed that serum vitamin D levels were lower in children with AD than in healthy children; however, the same relation was not observed between adults with AD and healthy adults. Serum 25-hydroxyvitamin D concentration was not significantly correlated with AD severity or serum LL-37 levels in our study population.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina D / Índice de Massa Corporal / Prevalência / Dermatite Atópica Tipo de estudo: Estudo de prevalência Limite: Adulto / Criança / Humanos Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina D / Índice de Massa Corporal / Prevalência / Dermatite Atópica Tipo de estudo: Estudo de prevalência Limite: Adulto / Criança / Humanos Idioma: Inglês Revista: Annals of Dermatology Ano de publicação: 2015 Tipo de documento: Artigo