Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI; Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI

Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI; Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI.

The Korean Journal of Parasitology ; : 123-126, 2005.

Artigo em Inglês | WPRIM | ID: wpr-115349

ABSTRACT

ABSTRACT

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.

Assuntos

Animais; Antimaláricos/química; Artemisininas/química; Cloroquina/farmacologia; Resistência a Medicamentos; Plasmodium falciparum/efeitos dos fármacos

Plasmodium falciparum; antimalarial activity; artemisinin; dihydroartemisinin; synthesis; natural product

Texto completo

Imprimir

XML

Buscar no Google

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasmodium falciparum / Resistência a Medicamentos / Cloroquina / Artemisininas / Antimaláricos Limite: Animais Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2005 Tipo de documento: Artigo

Similares

MEDLINE

LILACS

LIS

Texto completo

Imprimir

XML

Buscar no Google