Prognostic Factors Influencing Survival in Ampullary Carcinoma after Radical Resection
Journal of the Korean Surgical Society
;
: 408-412, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-115370
ABSTRACT
PURPOSE:
This retrospective study was aimed to determine prognostic factors after radical resection of an ampullary carcinoma.METHODS:
Medical records of patients with adenocarcinoma of the ampulla of Vater who had undergone pancreaticoduodenectomy between Dec. 1994 and May 2002 were reviewed. This study included 59 men and 40 women with a mean age of 58.9 years. 62 patients underwent Whipple procedures, 36 patients, pylorus preserving pancreaticoduodenectomy and 1 patient, total pancreatectomy. Actuarial survival rates were calculated using the Kaplan-Meier method. A Cox proportional hazards model was used to test the independent predictors of survival. P<0.05 was considered statistically significant.RESULTS:
The overall 5-year survival rate was 45.4% with 3% mortality and 34.3% morbidity. According to the pTNM stage, the 5-year survival rates were 91.7%, 54.3%, 28.5% and 0% at stages I, II, III, and IV (P<0.01), respectively. The patient survival was significantly impaired by the depth of invasion, lymph node metastasis and intraoperative transfusion (P<0.05). In a multivariate analysis, only lymph node metastasis was a statistically independent prognostic factor.CONCLUSION:
pTNM stage is a good prognostic indicator for an ampullary carcinoma after pancreaticoduodenectomy and patients with lymph node metastasis should be identified as high risk and considered as candidates for further adjuvant therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancreatectomia
/
Piloro
/
Ampola Hepatopancreática
/
Adenocarcinoma
/
Modelos de Riscos Proporcionais
/
Prontuários Médicos
/
Análise Multivariada
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Mortalidade
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
2003
Tipo de documento:
Artigo
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