Effect of terazosin on blood pressure and serum lipids in nild to moderate hypertension
Korean Circulation Journal
;
: 454-460, 1993.
Artigo
em Coreano
| WPRIM
| ID: wpr-115425
ABSTRACT
BACKGROUND:
We evaluated the antihypertensive effect, safety and effect on serum lipids of terazosin, second generation alpha1-blocker.METHODS:
Terazosin 1-4mg was adminstered once daily in 20 patients for 12 weeks with dose titration every 2 weeks.RESULTS:
1) The systolic and diastolic blood pressure were decreased from 170.0+/-13.0/104.0+/-6.0mmHg to 144.0+/-13.3/88.0+/-5.6mmHg(p<0.01), but the heart rate and body weight were independant of terazosin administration. 2) Total cholesterol was decreased significantly from 209.9+/-33.5mg/dL to 194.6+/-30.1mg/dL after 12 weeks treatment(p<0.05), triglyceride was decreased significantly from 185.4+/-37.0mg/dL to 168.9+/-35.0mg/dL(p<0.05). and LDL-cholesterol was decreased significantly from 134.5+/-31.9mg/dL to 122.7+/-29.9mg/dL(p<0.05), but HDL-cholesterol was increased significantly from 37.8+/-5.6mg/dL to 40.6+/-5.5mg/dL(p<0.05). 3) The adverse effects of terazosin were dizziness in 2, headache in 2, asthenia in 1, peripheral edema in 1 and skin rash in 1 patient, but were not troublesome enough to stop medication.CONCLUSIONS:
Terazosin 1-4mg once daily regimen was effective and safe as an antihypertensive agent, and moreover terazosin has favorable effects on serum lipids.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Astenia
/
Triglicerídeos
/
Pressão Sanguínea
/
Peso Corporal
/
Colesterol
/
Tontura
/
Edema
/
Exantema
/
Cefaleia
/
Frequência Cardíaca
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Circulation Journal
Ano de publicação:
1993
Tipo de documento:
Artigo
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