A Case of Langerhans Cell Histiocytosis Presented with Central Diabetes Insipidus / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 513-518, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-115700
ABSTRACT
Langerhans cell histiocytosis can cause central diabetes insipidus. Here, a case of Langerhans cell histiocytosis invading the pituitary stalk was experienced. The patient was 15 years old boy, with complaint of polydipsia and polyuria. A water deprivation test was carried out, and the urine osmolarity was increased from 165 to 469 mosm/kg following an injection of AVP to confirm the diagnosis of central diabetes insipidus. A pituitary function stimulation test gave a normal response. A sellar MRI was performed, which showed a thickened pituitary stalk mass (about 5.7mm), with an increased size, 6.9 mm, on a second MRI 2 month later. A tissue biopsy was performed, which showed aggregates of histiocytes and inflammatory cells, with prominent eosinophils (H&E), and also revealed strong reactivity to anti-CD1a antibody on the immunohistochemistry. After confirmative tissue diagnosis, the patient received radiotherapy (900 cGy). The thickened mass of the pituitary stalk disappeared on the MRI following the radiotherapy. The patient was managed with DDAVP nasal spray, after which the polyuric symptoms were completely relieved.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Concentração Osmolar
/
Hipófise
/
Poliúria
/
Radioterapia
/
Privação de Água
/
Biópsia
/
Imuno-Histoquímica
/
Imageamento por Ressonância Magnética
/
Histiocitose de Células de Langerhans
/
Diabetes Insípido Neurogênico
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Korean Society of Endocrinology
Ano de publicação:
2005
Tipo de documento:
Artigo
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