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Comparison of growth and pubertal progression in wild type female rats with different bedding types
Annals of Pediatric Endocrinology & Metabolism ; : 53-58, 2015.
Artigo em Inglês | WPRIM | ID: wpr-115862
ABSTRACT

PURPOSE:

Endocrine-disrupting chemicals interfere with the endocrine system and therefore affect growth and pubertal progression. The study aim was to compare the growth and pubertal progression in wild-type female rats with different bedding types.

METHODS:

Twenty 5-week-old female wild-type Sprague Dawley rats were randomly assigned to two groups with different bedding types one group received wood shaving bedding, while a second group received corncob bedding. We determined crown-rump length and body weight as anthropometric measurements and assessed the serum growth hormone (GH) and estradiol levels. The gh1 mRNA expression levels were compared using quantitative real time transcription polymerase chain reaction. The estrous cycle was evaluated by vaginal smear.

RESULTS:

The anthropometric measurements were not significantly different between the two groups. The mean relative expression of the gh1 gene was lower in the corncob bedding group than that in the wood shaving group (P=0.768). Meanwhile serum GH and estradiol were increased in the wood shaving bedding group; however this difference was not statistically significant. The time to first estrus and the length of the estrous cycle were increased in the corncob bedding group; the proportion of normal estrous cycles was also decreased. These findings indicate irregularities in the estrous cycle.

CONCLUSION:

Endocrine-disrupting chemicals in corncob bedding might be associated with time to first estrus and length of the estrous cycle. Therefore, the type of bedding should be considered as a factor affecting pubertal progression in rodents.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Roedores / Esfregaço Vaginal / Roupas de Cama, Mesa e Banho / Madeira / Peso Corporal / Estro / RNA Mensageiro / Hormônio do Crescimento / Reação em Cadeia da Polimerase / Puberdade Limite: Animais / Feminino / Humanos Idioma: Inglês Revista: Annals of Pediatric Endocrinology & Metabolism Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Roedores / Esfregaço Vaginal / Roupas de Cama, Mesa e Banho / Madeira / Peso Corporal / Estro / RNA Mensageiro / Hormônio do Crescimento / Reação em Cadeia da Polimerase / Puberdade Limite: Animais / Feminino / Humanos Idioma: Inglês Revista: Annals of Pediatric Endocrinology & Metabolism Ano de publicação: 2015 Tipo de documento: Artigo