Association of Interleukin-1alpha-889, beta-31, beta-511 Polymorphism with Risk of Bronchopulmonary Dysplasia
Neonatal Medicine
;
: 413-421, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-116170
ABSTRACT
PURPOSE:
Although improvements in neonatal care techniques have increased the survival rate of preterm infants, bronchopulmonary dysplasia (BPD) remains an important factor in neonatal mortality and morbidity. BPD is a multifactorial disease associated with genetic and clinical risk factors related to lung development and perinatal inflammation. Interleukin-1 (IL-1) is a crucial cytokine in the early stages of inflammation. In the present study, we aimed to determine the association between the IL-1 polymorphisms, clinical risk factors, and BPD in preterm infants.METHODS:
The study was performed who consented infants born at less than 34 weeks' gestation. The alleles of the 3 sites of the IL-1 gene (IL-1alpha-889, IL-1beta-31, and IL-1beta-511) were determined using Taqman(R)-based allelic discrimination assays. Clinical data were reviewed from the medical records.RESULTS:
A total of 31 infants with BPD and 73 control infants were enrolled in the study. The gestational age (P=0.001) and birth weight (P=0.001) were lower in the BPD group compared to those in the control group. The incidence of respiratory distress syndrome (RDS; P=0.002), patent ductus arteriosus (P=0.01), and retinopathy of prematurity (P<0.001) was higher in the BPD group compared to that in the control group. The frequency of IL-1alpha-889TT was higher in the BPD group (6.5% vs. 0.0%, P=0.028) compared to that in the control group. The frequencies of IL-1alpha-889T, IL-1beta-31T, and IL-1beta-511T did not differ between the BPD and control groups. In logistic regression analysis, gestational age and RDS were found to be associated with BPD.CONCLUSION:
IL-1alpha-889, IL-1beta-31, and IL-1beta-511 polymorphisms are not associated with the development of BPD in preterm infants.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peso ao Nascer
/
Retinopatia da Prematuridade
/
Displasia Broncopulmonar
/
Recém-Nascido Prematuro
/
Modelos Logísticos
/
Mortalidade Infantil
/
Prontuários Médicos
/
Incidência
/
Taxa de Sobrevida
/
Fatores de Risco
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Lactente
/
Recém-Nascido
/
Gravidez
Idioma:
Coreano
Revista:
Neonatal Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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