E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 349-354, 2011.
Artigo
em Coreano
| WPRIM
| ID: wpr-116310
ABSTRACT
BACKGROUND:
Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC.METHODS:
Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008.RESULTS:
The E6 oncoprotein was expressed in 29.4%of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients.CONCLUSION:
The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fumaça
/
Adenocarcinoma
/
Fumar
/
Proteínas Oncogênicas Virais
/
Prevalência
/
Fatores de Risco
/
Carcinoma Pulmonar de Células não Pequenas
/
Corantes
/
Neoplasias Pulmonares
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2011
Tipo de documento:
Artigo
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