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Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study
Yonsei Medical Journal ; : 1016-1021, 2011.
Artigo em Inglês | WPRIM | ID: wpr-116323
ABSTRACT

PURPOSE:

We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND

METHODS:

One hundred rats were assigned to six groups control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA.

RESULTS:

In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group.

CONCLUSION:

The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor / Artrite / Antagonistas da Serotonina / Carragenina / Analgesia por Acupuntura / Eletroacupuntura / Receptores Adrenérgicos / Receptores de Serotonina / Receptores Dopaminérgicos / Ratos Sprague-Dawley Limite: Animais Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor / Artrite / Antagonistas da Serotonina / Carragenina / Analgesia por Acupuntura / Eletroacupuntura / Receptores Adrenérgicos / Receptores de Serotonina / Receptores Dopaminérgicos / Ratos Sprague-Dawley Limite: Animais Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2011 Tipo de documento: Artigo