The Role of Glucose Transporter on Peritoneal Glucose Absorption and Fluid Transport / 대한신장학회잡지
Korean Journal of Nephrology
;
: 624-630, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-116371
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate the role of glucose transporter in peritoneal glucose and fluid transport.METHODS:
Male Sprague-Dawley rats were used. 5mL normal saline with(CB) and without(C) Cytochalasin B(1 muM) was intraperitoneally injected once. From the next day 25 mL commercial dialysis solutions containing 4.25% glucose was injected into the peritoneal cavity twice a day for 8 weeks in a half of each group(CB-IP, n=6 and C-IP, n=8). The other half of each group served as control without IP(C- Control, n=7 and CB-Control, n=7). A 2 hour dwell study was performed using dialysis solutions containing 4.25% glucose. Intraperitoneal volume(IPV) after 2 hours of dwell was measured and peritoneal fluid absorption rate(Qa) was calculated as RISA disappearance rate. Dialysate glucose amount remaining after 2hour dwell(DGA) was calculated and expressed as % of the initial value.RESULTS:
IPV was significantly higher in CB than in C in both IP and Control. IPV was significantly lower in C-IP than in C-Control and CB-IP while it was similar between CB-Control and CB-IP. Qa was significantly higher in IP than in Control. DGR was significantly higher in CB than in C and in control than in IP.CONCLUSION:
Longterm peritoneal exposure to high glucose dialysis solution increased peritoneal glucose absorption and decreased ultrafiltration volume in rat. A single IP use of glucose transporter inhibitor attenuated increased glucose absorption and decreased ultrafiltration after longterm peritoneal exposure to dialysate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cavidade Peritoneal
/
Líquido Ascítico
/
Ultrafiltração
/
Soluções para Diálise
/
Diálise Peritoneal Ambulatorial Contínua
/
Ratos Sprague-Dawley
/
Diálise
/
Absorção
/
Proteínas Facilitadoras de Transporte de Glucose
/
Glucose
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2001
Tipo de documento:
Artigo
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