Transcriptome Analysis of the Effects of Gomisin A on the Recovery of Carbon Tetrachloride-Induced Damage in Rat Liver / 한국실험동물학회지
Laboratory Animal Research
; : 161-169, 2011.
Article
em En
| WPRIM
| ID: wpr-116714
Biblioteca responsável:
WPRO
ABSTRACT
Gomisin A possesses a hepatic function-facilitating property in liver-injured rats. Its preventive action on carbon tetrachloride-induced cholestasis is due to maintenance of the function of the bile acids-independent fraction. To investigate alterations in gene expression after gomisin A treatment on injured rat liver, DNA microarray analyses were performed on a Rat 44K 4-Plex Gene Expression platform with duplicated reactions after gomisin A treatment. We identified 255 up-regulated and 230 down-regulated genes due to the effects of gomisin A on recovery of carbon tetrachloride-induced rat liver damage. For functional characterization of these genes, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biochemical pathways analyses were performed. Many up-regulated or down-regulated genes were related to cell cycle or focal adhesion and cell death genes, respectively. Our microarray experiment indicated that the liver repair mechanism induced by gomisin A was strongly associated with increased gene expressions related to cell cycle and suppression of the gene expression related in cell death.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Bile
/
Carbono
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Tetracloreto de Carbono
/
Expressão Gênica
/
Ciclo Celular
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Colestase
/
Genoma
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Morte Celular
/
Lignanas
/
Análise de Sequência com Séries de Oligonucleotídeos
Limite:
Animals
Idioma:
En
Revista:
Laboratory Animal Research
Ano de publicação:
2011
Tipo de documento:
Article