Reference Values for Peripheral Blood Lymphocyte Subsets in a Healthy Korean Population
Immune Network
;
: 289-295, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-116966
ABSTRACT
Flow cytometric immunophenotyping of peripheral blood lymphocyte subsets is a powerful tool for evaluating cellular immunity and monitoring immune-mediated diseases. The numbers and proportions of blood lymphocyte subsets are influenced by factors such as gender, age, ethnicity, and lifestyle. This study aimed to establish reference ranges for peripheral blood lymphocyte subsets in a healthy Korean population. Blood samples from 294 healthy adults were collected. Lymphocyte subsets were analyzed using a single-platform method with a flow cytometer; white blood cells and lymphocytes were analyzed using an automated hematology analyzer. The mean value of the white blood cell count was 5,665 cells/microl, and the mean values of the subtype counts (percentages) were as follows lymphocytes, 1,928 cells/microl (35.08%); CD3+ cells, 1,305 cells/microl (67.53%); CD3+CD4+ cells, 787 cells/microl (40.55%); CD3+CD8+ cells, 479 cells/microl (25.23%); CD3-CD19+ cells, 203 cells/microl (10.43%); and CD3-CD56+ cells, 300 cells/microl (15.63%). Additionally, the CD4+/CD8+ ratio was 1.81. In this study, gender and age significantly influenced blood lymphocyte subsets. Our results demonstrate that, as with other populations, a healthy Korean population has its own, region-specific, lymphocyte subset reference ranges.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Valores de Referência
/
Linfócitos
/
Imunofenotipagem
/
Subpopulações de Linfócitos
/
Citometria de Fluxo
/
Hematologia
/
Imunidade Celular
/
Contagem de Leucócitos
/
Leucócitos
/
Estilo de Vida
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2014
Tipo de documento:
Artigo
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